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Article

Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction.

The Journal of biological chemistry - 3 Oct 2003

Tsuruta Daisuke, Hopkinson Susan B, Lane Kimberly D, Werner Michael E, Cryns Vincent L, Jones Jonathan C R

Abstract excerpt

Within each hemidesmosome, alpha6beta4 integrin plays a crucial role in hemidesmosome assembly by binding to laminin-5 in the basement membrane zone of epithelial tissue. Recent analyses have implicated "specificity-determining loops" (SDLs) in the I-like domain of beta integrin in regulating lig...

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Identifiers

PMID: 12867433
DOI: 10.1074/jbc.M301637200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12867433-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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