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Histone H1 variant, H1R is involved in DNA damage response.

DNA repair - 1 Nov 2007

Hashimoto Hideharu, Sonoda Eiichiro, Takami Yasunari, Kimura Hiroshi, Nakayama Tatsuo, Tachibana Makoto, Takeda Shunichi, Shinkai Yoichi

Abstract excerpt

In Saccharomyces cerevisiae, the linker histone HHO1 is involved in DNA repair. In higher eukaryotes, multiple variants of linker histone H1 exist but their involvement in the DNA damage response is unknown. To address this issue, we examined sensitivity to genotoxic agents in chicken DT40 cells lacking specific H1 variants. Among the six H1 variant mutants, only H1R(-/-) DT40 cells exhibited increased...

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Identifiers

PMID: 17613284
DOI: 10.1016/j.dnarep.2007.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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