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Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.

Experimental and molecular pathology - 1 Apr 2013

Kanzaki Hirotaka, Ohtaki Akashi, Merchant Faisal K, Greene Mark I, Murali Ramachandran

Abstract excerpt

Osteoprotegerin (OPG) is a soluble receptor expressed in the serum of patients with diabetes, arthritis and pancreatic cancer. While OPG has been considered a tumor survival factor for bone metastasizing breast and prostate cancers, the role of OPG in pancreatic cancer, which itself rarely metastasizes to bone, is not known. Pancreatic ductal adenocarcinoma (PDAC) cell lines were found to secrete OPG and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23219833
DOI: 10.1016/j.yexmp.2012.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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