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Article

Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis.

Molecular cancer therapeutics - 1 Dec 2007

Locklin Rachel M, Federici Ermanno, Espina Belen, Hulley Philippa A, Russell R Graham G, Edwards Claire M

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a tumor necrosis factor superfamily member, targets death receptors and selectively kills malignant cells while leaving normal cells unaffected. However, unlike most cancers, many osteosarcomas are resistant to TRAIL. To investigate this resistance, we characterized the response of MG-63 osteosarcoma cells and hPOB-tert osteoblast-like cells to...

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Identifiers

PMID: 18065493
DOI: 10.1158/1535-7163.MCT-07-0275
PMCID: PMC2816033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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