Article
Chromosome stability differs in cloned mouse embryos and derivative ES cells.
Developmental biology - 15 Aug 2007
Balbach Sebastian T, Jauch Anna, Böhm-Steuer Barbara, Cavaleri Fatima M, Han Yong-Mahn, Boiani Michele
Abstract excerpt
The mechanisms that have evolved to maintain genome stability during cell cycle progression are challenged when a somatic cell nucleus is placed in a meiotic environment such as the ooplasm. Chromosomal spindle aberrations ensue in the majority of reconstructed oocytes within 2 h of transplantation, but it is not known if they recover or persist with the onset of embryonic divisions. We analyzed the chromosomal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
