Article
DNA hypermethylation and aberrant expression of the EMP3 gene at 19q13.3 in Human Gliomas.
Brain pathology (Zurich, Switzerland) - 1 Oct 2007
Kunitz Annegret, Wolter Marietta, van den Boom Jörg, Felsberg Jörg, Tews Björn, Hahn Meinhard, Benner Axel, Sabel Michael, Lichter Peter, Reifenberger Guido, von Deimling Andreas, Hartmann Christian
Abstract excerpt
Allelic losses on 19q are found in the majority of oligodendroglial tumors and approximately one-third of diffuse astrocytomas. However, the tumor suppressor genes (TSG) on 19q are still elusive. Using cDNA microarray expression profiling, EMP3 at 19q13.3 was among those genes showing the most pronounced expression differences. In line with this, other authors reported EMP3 as being epigenetically silenced in...
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