Article
Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.
Neuropathology and applied neurobiology - 1 Apr 2010
Qu M, Jiao H, Zhao J, Ren Z-P, Smits A, Kere J, Nistér M
Abstract excerpt
AIM: Loss of heterozygosity at 19q13.3 is a common genetic change in human gliomas, indicating yet unknown glial-specific tumour suppressor genes in this chromosome region. NCX2/SLC8A2 located on chromosome 19q13.32 encodes a Na(+)/Ca(2+) exchanger, which contributes to intracellular Ca(2+) homeostasis. Its expression is restricted to brain, and it is present neither in other normal tissues nor in gliomas at any...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.