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Article

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.

The Journal of biological chemistry - 31 Aug 2007

Aguirre J Ignacio, Plotkin Lilian I, Gortazar Arancha R, Millan Marta Martin, O'Brien Charles A, Manolagas Stavros C, Bellido Teresita

Abstract excerpt

Bone senses and adapts to meet mechanical needs by means of an extensive mechanotransduction network comprising osteocytes (former osteoblasts entrapped in mineral) and their cytoplasmic projections through which osteocytes communicate with osteoblasts and osteoclasts on the bone surface. Mechanical stimulation promotes osteocyte (and osteoblast) survival by activating the extracellular signal-regulated kinases,...

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Source

Identifiers

PMID: 17609204
DOI: 10.1074/jbc.M702231200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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