Article
Interactions between estrogen and mechanical strain effects on U2OS human osteosarcoma cells are not influenced by estrogen receptor type.
Bone - 1 Nov 2004
Lima Florence, Vico Laurence, Lafage-Proust Marie-Hélène, van der Saag Paul, Alexandre Christian, Thomas Thierry
Abstract excerpt
Estrogens (E) and mechanical strain (MS) exert direct effects on osteoblast activity, with good evidence of interactions between their respective effects. Osteoblasts express both forms of estrogen receptors (ER) ERalpha and ERbeta, and previous studies have suggested a specific role for each receptor. Therefore, our working hypothesis was that the interactions between E and MS on osteoblast activity vary...
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