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Article

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells.

The Journal of biological chemistry - 20 Jul 2007

McNutt Markey C, Lagace Thomas A, Horton Jay D

Abstract excerpt

Proprotein convertase subtilisin/kexin type 9 (PCSK9), a member of the proteinase K subfamily of subtilases, promotes internalization and degradation of low density lipoprotein receptors (LDLRs) after binding the receptor on the surface of hepatocytes. PCSK9 has autocatalytic activity that releases the prodomain at the N terminus of the protein. The prodomain remains tightly associated with the catalytic domain...

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Source

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Identifiers

PMID: 17537735
DOI: 10.1074/jbc.C700095200
PMCID: PMC13276728

Genes

PCSK9
LDLR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells.PMID 17537735Read ↗

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