Importance in timing of cyclophosphamide on the enhancement of interleukin-2-induced cytolysis.

doi:10.1007/BF01741339

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Article

Importance in timing of cyclophosphamide on the enhancement of interleukin-2-induced cytolysis.

Cancer immunology, immunotherapy : CII - 1 Jan 1991

Katsanis E, Bausero M A, Ochoa A C, Loeffler C M, Blazar B R, Leonard A S, Anderson P M

Abstract excerpt

We investigated the in vivo effects of cyclophosphamide (CY) on interleukin-2(IL-2)-induced cytolytic function and spleen cell immunophenotype. Pretreatment of A/J mice with CY (25 mg/kg or 75 mg/kg) i.p. on days -10 and -15 followed by IL-2 (50,000 U i.p. on days 0 to +3) resulted in increased l...

Topics

Animals
Antineoplastic Combined Chemotherapy Protocols
Cyclophosphamide
Female
Interleukin-2
Killer Cells, Natural
Mice
Neoplasms, Experimental
Phenotype
Spleen
Time Factors

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