Article
Importance in timing of cyclophosphamide on the enhancement of interleukin-2-induced cytolysis.
Cancer immunology, immunotherapy : CII - 1 Jan 1991
Katsanis E, Bausero M A, Ochoa A C, Loeffler C M, Blazar B R, Leonard A S, Anderson P M
Abstract excerpt
We investigated the in vivo effects of cyclophosphamide (CY) on interleukin-2(IL-2)-induced cytolytic function and spleen cell immunophenotype. Pretreatment of A/J mice with CY (25 mg/kg or 75 mg/kg) i.p. on days -10 and -15 followed by IL-2 (50,000 U i.p. on days 0 to +3) resulted in increased lysis of YAC-1 target cells compared to the group receiving IL-2 without previous CY therapy. In contrast, when CY was...
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