Article
Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome.
Oncogene - 3 Sept 1998
Birch J M, Blair V, Kelsey A M, Evans D G, Harris M, Tricker K J, Varley J M
Abstract excerpt
The Li-Fraumeni cancer predisposition syndrome is associated with germline TP53 mutations in the majority of families. We have investigated cancer incidence in 34 Li-Fraumeni families, according to their constitutional TP53 mutation status. Families with germline missense mutations in the core DN...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Chi-Square Distribution
- Child
- Child, Preschool
- Cohort Studies
- DNA Mutational Analysis
- Family
- Family Health
- Female
- Genotype
- Germ-Line Mutation
- Humans
- Infant
- Infant, Newborn