Article
Novel components of an active mitochondrial K(+)/H(+) exchange.
The Journal of biological chemistry - 7 May 2010
Zotova Ludmila, Aleschko Markus, Sponder Gerhard, Baumgartner Roland, Reipert Siegfried, Prinz Monika, Schweyen Rudolf J, Nowikovsky Karin
Abstract excerpt
Defects of the mitochondrial K(+)/H(+) exchanger (KHE) result in increased matrix K(+) content, swelling, and autophagic decay of the organelle. We have previously identified the yeast Mdm38 and its human homologue LETM1, the candidate gene for seizures in Wolf-Hirschhorn syndrome, as essential components of the KHE. In a genome-wide screen for multicopy suppressors of the pet(-) (reduced growth on nonfermentable...
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