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FYN is required for ARHGEF16 to promote proliferation and migration in colon cancer cells

7 Aug 2020

Abstract excerpt

ARHGEF16 is a recently identified Rho-family guanine nucleotide exchange factor (GEF) that has been implicated in the activation of Rho-family GTPases such as Rho G, Rac, and Cdc42. However, its functions in colon cancer cell proliferation and migration are not well understood. In this study, we showed that ARHGEF16 was highly expressed in clinical specimens of colon cancer. In colon cancer cells,...

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PMID: 32811808
DOI: 10.1038/s41419-020-02830-1

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