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Article

Clinical, structural and functional implications of mutations and polymorphisms in human NADPH P450 oxidoreductase.

Fundamental & clinical pharmacology - 1 Aug 2007

Flück Christa E, Nicolo Catherine, Pandey Amit V

Abstract excerpt

Cytochrome P450 proteins are involved in metabolism of drugs and xenobiotics. In the endoplasmic reticulum a single nicotinamide adenine dinucleotide phosphate (NADPH) P450 oxidoreductase (POR) supplies electrons to all microsomal P450s for catalytic activity. POR is a flavoprotein that contains both flavin mononucleotide and flavin adenine dinucleotide as cofactors and uses NADPH as the source of electrons. We...

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Source

Identifiers

PMID: 17635179
DOI: 10.1111/j.1472-8206.2007.00520.x

Genes

POR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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