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Article

HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2007

Zeng Yan, Danielson Keith G, Albert Todd J, Shapiro Irving M, Risbud Makarand V

Abstract excerpt

UNLABELLED: The regulation of galectin-3 expression in skeletal tissues is not completely understood. Our studies indicate that HIF-1 alpha regulates galectin-3 expression by interacting with hypoxia regulatory elements in the promoter region. Finally, we show that galectin-3 serves a prosurvival role in the intervertebral disc. INTRODUCTION: Earlier reports indicated that galectin-3 (gal-3) is highly expressed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17592963
DOI: 10.1359/jbmr.070620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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