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Article

Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β Pathways

1 Nov 2002

Abstract excerpt

Endoglin is a transforming growth factor-beta (TGF-beta) co-receptor expressed mainly on endothelial cells and involved in cardiovascular development, angiogenesis, and vascular remodeling. This is illustrated by the fact that mutations in the endoglin gene give rise to hereditary hemorrhagic telangiectasia type 1, a dominant vascular disease with clinical manifestations that originate by a mechanism of...

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Identifiers

PMID: 12228247
DOI: 10.1074/jbc.m207160200

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β PathwaysPMID 12228247Read ↗

Identification of a Critical Sp1 Site within the Endoglin Promoter and Its Involvement in the Transforming Growth Factor-β StimulationSemantic proximity Read ↗

Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1Semantic proximity Read ↗

Interaction and functional interplay between endoglin and ALK‐1, two components of the endothelial transforming growth factor‐β receptor complexSemantic proximity Read ↗

Endoglin Regulates the Activation and Quiescence of Endothelium by Participating in Canonical and Non-Canonical TGF-β Signaling PathwaysSemantic proximity Read ↗

Novel biochemical pathways of endoglin in vascular cell physiologySemantic proximity Read ↗

Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-βSemantic proximity Read ↗

Endoglin: a critical mediator of cardiovascular healthSemantic proximity Read ↗

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.Semantic proximity Read ↗

Genetic and molecular pathogenesis of hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor GrowthSemantic proximity Read ↗

Endoglin-mediated vascular remodeling: mechanisms underlying hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

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