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Article

Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot-and-mouth disease virus RNA

25 Jun 2007

Abstract excerpt

The foot-and-mouth disease virus (FMDV) RNA contains two in-frame AUG codons separated by 84 nt that direct translation initiation of the viral polyprotein. The mechanism of initiation at the IRES-proximal AUG codon (AUG1) has been previously analyzed, whereas no data on factor requirements for AUG2 have been reported. Here, using the method of 48S translation initiation complex reconstitution, we show that eIF1...

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PMID: 17592045
DOI: 10.1261/rna.469707

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Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot-and-mouth disease virus RNAPMID 17592045Read ↗

Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virusSemantic proximity Read ↗

Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo.Semantic proximity Read ↗

eIF5 and eIF5B together stimulate 48S initiation complex formation during ribosomal scanning.Semantic proximity Read ↗

Mechanisms Leading to the Loss of AUG Codon Function as a Translation InitiatorSemantic proximity Read ↗

Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cellsSemantic proximity Read ↗

Dual initiation sites of protein synthesis on foot‐and‐mouth disease virus RNA are selected following internal entry and scanning of ribosomes in vivo.Semantic proximity Read ↗

Translation initiation mediated by RNA loopingSemantic proximity Read ↗

Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex.Semantic proximity Read ↗

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.Semantic proximity Read ↗

IRES interaction with translation initiation factors: Functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GIISemantic proximity Read ↗

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation ComplexesSemantic proximity Read ↗

Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA.Semantic proximity Read ↗

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