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Article

IRES interaction with translation initiation factors: Functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII

1 Sept 2001

Abstract excerpt

Translation initiation promoted by picornavirus internal ribosome entry site (IRES) elements is dependent on the association of specific IRES sequences to the initiation factor eIF4G. However the RNA determinants interacting with other components of the translational machinery are still unknown. In this study, we have identified novel RNA-protein interactions between the foot-and-mouth disease virus (FMDV) IRES...

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Identifiers

PMID: 11565745
DOI: 10.1017/s1355838201010433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IRES interaction with translation initiation factors: Functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GIIPMID 11565745Read ↗

Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo.Semantic proximity Read ↗

G3 BP 1 interacts directly with the FMDV IRES and negatively regulates translationSemantic proximity Read ↗

Riboproteomic analysis of polypeptides interacting with the internal ribosome‐entry site element of foot‐and‐mouth disease viral RNASemantic proximity Read ↗

Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation.Semantic proximity Read ↗

Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translationSemantic proximity Read ↗

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Sequence and secondary structure requirements in a highly conserved element for foot-and-mouth disease virus internal ribosome entry site activity and eIF4G binding.Semantic proximity Read ↗

Functional involvement of polypyrimidine tract-binding protein in translation initiation complexes with the internal ribosome entry site of foot-and-mouth disease virusSemantic proximity Read ↗

RNA-Binding Proteins as Regulators of Internal Initiation of Viral mRNA TranslationSemantic proximity Read ↗

IRES-driven translation is stimulated separately by the FMDV 3'-NCR and poly(A) sequencesSemantic proximity Read ↗

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding ProteinsSemantic proximity Read ↗

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