Article
Inherited diseases of the glomerular basement membrane.
Nature clinical practice. Nephrology - 1 Jan 2008
Gubler Marie Claire
Abstract excerpt
The glomerular basement membrane (GBM) is a specialized form of basement membrane that has a major role in the maintenance of the glomerular filtration barrier. Like all basement membranes, it contains four main components: type IV collagen, laminin, nidogen, and heparan sulfate proteoglycans. Different isoforms of these large molecules are produced. These isoforms have a tissue-specific distribution; in the...
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