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Article

Silencing gene therapy for mutant membrane, secretory, and lipid proteins in retinitis pigmentosa (RP).

Medical hypotheses - 1 Jan 2008

Shinohara Toshimichi, Mulhern Michael L, Madson Christian J

Abstract excerpt

A mutation in retinal photoreceptor-specific proteins causes nearly 50% of retinitis pigmentosa (RP) cases; the other 50% is called sporadic RP, the etiology of which is unknown. To alleviate RP development, gene therapies, including insertion of a wild type gene or replacement of mutant genes, have been conducted in animal models. The result was not always satisfactory. We found that a mutant misfolded rhodopsin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17590524
DOI: 10.1016/j.mehy.2007.04.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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