Article
The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.
Molecular brain - 16 Jun 2014
Yoshida Tetsu, Ozawa Yoko, Suzuki Keiichiro, Yuki Kenya, Ohyama Manabu, Akamatsu Wado, Matsuzaki Yumi, Shimmura Shigeto, Mitani Kohnosuke, Tsubota Kazuo, Okano Hideyuki
Abstract excerpt
BACKGROUND: Retinitis pigmentosa (RP) is an inherited human retinal disorder that causes progressive photoreceptor cell loss, leading to severe vision impairment or blindness. However, no effective therapy has been established to date. Although genetic mutations have been identified, the available clinical data are not always sufficient to elucidate the roles of these mutations in disease pathogenesis, a...
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