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Article

Genomic DNA nanoparticles rescue rhodopsin-associated retinitis pigmentosa phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2015

Han Zongchao, Banworth Marcellus J, Makkia Rasha, Conley Shannon M, Al-Ubaidi Muayyad R, Cooper Mark J, Naash Muna I

Abstract excerpt

Mutations in the rhodopsin gene cause retinal degeneration and clinical phenotypes including retinitis pigmentosa (RP) and congenital stationary night blindness. Effective gene therapies have been difficult to develop, however, because generating precise levels of rhodopsin expression is critical; overexpression causes toxicity, and underexpression would result in incomplete rescue. Current gene delivery...

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Identifiers

PMID: 25713057
DOI: 10.1096/fj.15-270363
PMCID: PMC4447225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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