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Article

Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.

PLoS pathogens - 1 Jun 2007

An Ping, Wang Li Hua, Hutcheson-Dilks Holli, Nelson George, Donfield Sharyne, Goedert James J, Rinaldo Charles R, Buchbinder Susan, Kirk Gregory D, O'Brien Stephen J, Winkler Cheryl A

Abstract excerpt

Human cyclophilin A, or CypA, encoded by the gene peptidyl prolyl isomerase A (PPIA), is incorporated into the HIV type 1 (HIV-1) virion and promotes HIV-1 infectivity by facilitating virus uncoating. We examined the effect of single nucleotide polymorphisms (SNPs) and haplotypes within the PPIA gene on HIV-1 infection and disease progression in five HIV-1 longitudinal history cohorts. Kaplan-Meier survival...

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Source

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Identifiers

PMID: 17590083
DOI: 10.1371/journal.ppat.0030088
PMCID: PMC1894826

Genes

PPIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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