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Article

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Science (New York, N.Y.) - 22 Jun 2007

Rock Fernando L, Mao Weimin, Yaremchuk Anya, Tukalo Mikhail, Crépin Thibaut, Zhou Huchen, Zhang Yong-Kang, Hernandez Vincent, Akama Tsutomu, Baker Stephen J, Plattner Jacob J, Shapiro Lucy, Martinis Susan A, Benkovic Stephen J, Cusack Stephen, Alley M R K

Abstract excerpt

Aminoacyl-transfer RNA (tRNA) synthetases, which catalyze the attachment of the correct amino acid to its corresponding tRNA during translation of the genetic code, are proven antimicrobial drug targets. We show that the broad-spectrum antifungal 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), in development for the treatment of onychomycosis, inhibits yeast cytoplasmic leucyl-tRNA synthetase by...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bridged Bicyclo Compounds, Heterocyclic

Share to Drug Resistance, Fungal

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Identifiers

PMID: 17588934
DOI: 10.1126/science.1142189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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