Article
Oxidative microenvironment exerts an opposite regulatory effect on cytokine production by Th1 and Th2 cells.
Molecular immunology - 1 Jan 2008
Frossi Barbara, De Carli Marco, Piemonte Marco, Pucillo Carlo
Abstract excerpt
Oxidative stress occurs in allergic disorders and immunologic inflammatory responses and reactive oxygen metabolites have an additional role of cell-signaling mediators, influencing many biological processes. Using in vitro derived Th1 and Th2 clones or T cells derived from autoimmune thyroiditis we study the ability of Th1 or Th2 cells to expand and produce cytokine in an oxidative environment. We found that...
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