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Article

Chronic inflammation and oxidative stress in human carcinogenesis.

International journal of cancer - 1 Dec 2007

Federico Alessandro, Morgillo Floriana, Tuccillo Concetta, Ciardiello Fortunato, Loguercio Carmela

Abstract excerpt

A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic transformation. In general, the longer the inflammation persists, the higher the risk of cancer. A mutated cell is a sine qua non for carcinogenesis. Inflammatory processes may induce DNA mutations in cells via oxidative/nitrosative stress. This condition occurs when the generation of free radicals and active intermediates...

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Identifiers

PMID: 17893868
DOI: 10.1002/ijc.23192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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