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Article

The motif of SPARC that inhibits DNA synthesis is not a nuclear localization signal.

Journal of molecular biology - 24 Aug 2007

Kosman Jeffrey, Carmean Nicole, Leaf Elizabeth M, Dyamenahalli Kiran, Bassuk James A

Abstract excerpt

SPARC (secreted protein acidic and rich in cysteine), although primarily known as a secreted, matricellular protein, has also been identified in urothelial cell nuclei. Many biological activities, including inhibition of cell adhesion and repression of DNA synthesis, have been ascribed to SPARC, but the influence of its intracellular localization on each of these activities is unknown. When exposed by epitope...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17586526
DOI: 10.1016/j.jmb.2007.04.088

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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