Quantitative dissection of clone-specific growth rates in cultured malaria parasites.

doi:10.1016/j.ijpara.2007.05.003

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Article

Quantitative dissection of clone-specific growth rates in cultured malaria parasites.

International journal for parasitology - 1 Dec 2007

Reilly Heather B, Wang Hongjian, Steuter John A, Marx Anastasia M, Ferdig Michael T

Abstract excerpt

Measurement of parasite proliferation in cultured red blood cells underpins many facets of malaria research, from drug sensitivity assays to assessing the impact of experimentally altered genes on parasite growth, virulence and fitness. Pioneering efforts to grow Plasmodium falciparum in cultured red blood cells revolutionised malaria research and spurred the development of semi-high-throughput growth assays...

Topics

Animals
Cells, Cultured
Clone Cells
Drug Resistance
Erythrocytes
Hypoxanthine
Life Cycle Stages
Merozoites
Parasitology
Phenotype
Plasmodium falciparum
Schizonts
Species Specificity
Virulence

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Identifiers

PMID: 17585919
DOI: 10.1016/j.ijpara.2007.05.003
PMCID: PMC2268714

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