Article
New Assays to Characterise Growth-Related Phenotypes of Plasmodium falciparum Reveal Variation in Density-Dependent Growth Inhibition between Parasite Lines.
PloS one - 1 Jan 2016
Rovira-Graells Núria, Aguilera-Simón Sara, Tintó-Font Elisabet, Cortés Alfred
Abstract excerpt
The growth phenotype of asexual blood stage malaria parasites can influence their virulence and also their ability to survive and achieve transmission to the next host, but there are few methods available to characterise parasite growth parameters in detail. We developed a new assay to measure growth rates at different starting parasitaemias in a 96-well format and applied it to characterise the growth of...
Topics
- Erythrocytes
- Flow Cytometry
- Genomics
- Humans
- Life Cycle Stages
- Malaria, Falciparum
- Merozoites
- Microarray Analysis
- Parasitemia
- Phenotype
- Plasmodium falciparum
- Proteomics
- Schizonts