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Article

Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.

Human molecular genetics - 1 Nov 2007

Demura Masashi, Martin Regina M, Shozu Makio, Sebastian Siby, Takayama Kazuto, Hsu Wei-Tong, Schultz Roger A, Neely Kirk, Bryant Michael, Mendonca Berenice B, Hanaki Keiichi, Kanzaki Susumu, Rhoads David B, Misra Madhusmita, Bulun Serdar E

Abstract excerpt

Production of appropriate quantities of estrogen in various tissues is essential for human physiology. A single gene (CYP19), regulated via tissue-specific promoters, encodes the enzyme aromatase, which catalyzes the key step in estrogen biosynthesis. Aromatase excess syndrome is inherited as autosomal dominant and characterized by high systemic estrogen levels, short stature, prepubertal gynecomastia and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17584767
DOI: 10.1093/hmg/ddm145

Genes

CGNL1
DMXL2
MAPK6
TLN2
TMOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.PMID 17584767Read ↗

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A Highly Complex Organization of the Regulatory Region of the Human CYP19 (Aromatase) Gene Revealed by the Human Genome ProjectSemantic proximity Read ↗

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A Highly Complex Organization of the Regulatory Region of the Human CYP19 (Aromatase) Gene Revealed by the Human Genome ProjectSemantic proximity Read ↗

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