Article

A Highly Complex Organization of the Regulatory Region of the Human CYP19 (Aromatase) Gene Revealed by the Human Genome Project

2001-10-01

Abstract excerpt

Aromatase, the key enzyme for E biosynthesis, is encoded by a single copy of the CYP19 gene, localized at chromosome 15q21.21 (1, 2). In most vertebrates, aromatase is expressed only in gonads and the brain, whereas primates express this gene in additional extragonadal sites (1). Aromatase expression and E production continuously increase, as evolutionary tree progresses and reach the maximum in the human. This is...

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Literature Corpus work: afad5845-55ec-5863-b4a6-a88e43bc0355
DOI: 10.1210/jc.86.10.4600

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