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Alternatively Spliced Transcripts of the Aromatase Cytochrome P450 (<i>CYP19</i>) Gene in Adipose Tissue of Women<sup>1</sup>

1 Jan 1997

Abstract excerpt

Estrogen biosynthesis in adipose tissue has assumed great significance in terms of a number of estrogen-related diseases. The biosynthesis of estrogens from C19 steroids is catalyzed by a specific form of cytochrome P450, namely aromatase cytochrome P450 (P450arom; the product of the CYP19 gene). The human CYP19 gene comprises nine coding exons, II-X, and its transcripts are expressed in the ovary, placenta,...

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PMID: 8989235
DOI: 10.1210/jcem.82.1.3655

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Alternatively Spliced Transcripts of the Aromatase Cytochrome P450 (<i>CYP19</i>) Gene in Adipose Tissue of Women<sup>1</sup>PMID 8989235Read ↗

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A Highly Complex Organization of the Regulatory Region of the Human CYP19 (Aromatase) Gene Revealed by the Human Genome ProjectSemantic proximity Read ↗

Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.Semantic proximity Read ↗

Dual Regulation of Promoter II- and Promoter 1f-Derived Cytochrome P450 Aromatase Transcripts in Equine Granulosa Cells during Human Chorionic Gonadotropin-Induced Ovulation: A Novel Model for the Study of Aromatase Promoter Switching1Semantic proximity Read ↗

The Aromatase Cytochrome P-450 and Its Clinical ImpactSemantic proximity Read ↗

Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads.Semantic proximity Read ↗

Differences in Expression of Genes Related to Steroidgenesis in Abdominal Subcutaneous Adipose Tissue of Pregnant Women with and without PCOSSemantic proximity Read ↗

Exon-specific northern analysis and rapid amplification of cDNA ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P450 (CYP19) expression in human ovarySemantic proximity Read ↗

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