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Article

Inflamm‐ageing and lifelong antigenic load as major determinants of ageing rate and longevity

11 Mar 2005

Abstract excerpt

Immunosenescence is the consequence of the continuous attrition caused by chronic antigenic stress. The most important characteristics of immunosenescence (accumulation of memory and effector T cells, reduction of naive T cells, shrinkage of T cell repertoire, reduction of the immunological space) are compatible with this assumption. Immunosenescence can be taken as proof that the beneficial effects of the immune...

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PMID: 15811314
DOI: 10.1016/j.febslet.2005.02.055

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