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Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer

6 Nov 2023

Abstract excerpt

BACKGROUND: SARS-CoV-2, the agent responsible for the COVID-19 pandemic, enters cells through viral spike glycoprotein binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). Given the lack of effective antivirals targeting SARS-CoV-2, we previously utilized systematic evolution of ligands by exponential enrichment (SELEX) and selected fluoro-arabino nucleic acid (FANA) aptamer R8-9 that was...

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PMID: 37932762
DOI: 10.1186/s12931-023-02590-4

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