Article
Probing sequence variation in the receptor-targeting domain of feline leukemia virus envelope proteins with peptide display libraries.
Journal of virology - 1 Feb 2005
Bupp Keith, Sarangi Anindita, Roth Monica J
Abstract excerpt
Determinants of cellular tropism and receptor targeting lie within a short peptide in the Vr1 region of the envelope (Env) proteins of feline leukemia virus (FeLV) subgroups A and C. Libraries of FeLV Env proteins with random amino acid substitutions in the peptide were screened for their ability to deliver a marker gene to D17 and AH927 cells. Screening on D17 canine cells yielded D17-specific Env proteins that...
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