Article
COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma.
The American journal of gastroenterology - 1 Nov 2007
Moons Leon M G, Kuipers Ernst J, Rygiel Agnieszka M, Groothuismink Anthonie Z M, Geldof Han, Bode Willem A, Krishnadath Kausilia K, Bergman Jacques J G H M, van Vliet Arnoud H M, Siersema Peter D, Kusters Johannes G
Abstract excerpt
BACKGROUND: Neoplastic progression of BE towards EAC is associated with increased expression of COX-2. Increased COX-2 expression and enzyme activity is linked to the COX-2 CA haplotype, which consists of two gene polymorphisms in the COX-2 promoter. AIM: To study the impact of COX-2 haplotypes on the risk of developing EAC in patients with different forms of gastroesophageal reflux disease including BE. METHODS:...
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