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Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions

1 Jan 2014

Abstract excerpt

The pregnancy-specific glycoproteins (PSGs) are the most abundant trophoblastic proteins in maternal blood during human pregnancy and they appear to be exclusive to species with hemochorial placentation. There are ten protein-coding human PSG genes (PSG1 - PSG9, PSG11) and also multiple PSG genes in non-human primates, rodents and bats. Several studies indicate that PSGs have immunoregulatory, pro-angiogenic, and...

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PMID: 25023693
DOI: 10.1387/ijdb.130329gd

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