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Article

Siglec-6 is expressed in gestational trophoblastic disease and affects proliferation, apoptosis and invasion

22 Oct 2012

Abstract excerpt

Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are characterized by excess proliferation, whereas gestational trophoblastic neoplasias (GTN) have...

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PMID: 23089140
DOI: 10.1530/erc-11-0379

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