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Placental Protein 13 (PP13) â€“ A Placental Immunoregulatory Galectin Protecting Pregnancy

20 Aug 2014

Abstract excerpt

Galectins are glycan-binding proteins that regulate innate and adaptive immune responses, and some confer maternal-fetal immune tolerance in eutherian mammals. A chromosome 19 cluster of galectins has emerged in anthropoid primates, species with deep placentation and long gestation. Three of the five human cluster galectins are solely expressed in the placenta, where they may confer additional immunoregulatory...

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PMID: 25191322
DOI: 10.3389/fimmu.2014.00348

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