Article
Specific membrane binding of neurotoxin II can facilitate its delivery to acetylcholine receptor.
Biophysical journal - 7 Oct 2009
Lesovoy Dmitry M, Bocharov Eduard V, Lyukmanova Ekaterina N, Kosinsky Yurij A, Shulepko Mikhail A, Dolgikh Dmitry A, Kirpichnikov Mikhail P, Efremov Roman G, Arseniev Alexander S
Abstract excerpt
The action of three-finger snake alpha-neurotoxins at their targets, nicotinic acetylcholine receptors (nAChR), is widely studied because of its biological and pharmacological relevance. Most such studies deal only with ligands and receptor models; however, for many ligand/receptor systems the membrane environment may affect ligand binding. In this work we focused on binding of short-chain alpha-neurotoxin II...
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