Article
Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.
Bioorganic & medicinal chemistry letters - 15 Aug 2007
Wang Xiangdong Alan, Cianci Christopher W, Yu Kuo-Long, Combrink Keith D, Thuring Jan W, Zhang Yi, Civiello Rita L, Kadow Kathleen F, Roach Julia, Li Zhufang, Langley David R, Krystal Mark, Meanwell Nicholas A
Abstract excerpt
Extensive SAR studies and optimization of ADME properties of benzimidazol-2-one derivatives led to the identification of BMS-433771 (3) as an orally active RSV fusion inhibitor. In order to extend the structure-activity relationships for this compound series, substitution of the benzimidazole ring was examined with a view to establishing additional productive interactions between the inhibitor and functionality...
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