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Structural Optimization and MD Simulation Study of Benzimidazole Derivatives as Potent Mutant FLT3 Kinase Inhibitors Targeting AML

1 May 2025

Abstract excerpt

ABSTRACT Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor survival rates in adults, posing a significant economic burden. FMS‐like tyrosine kinase 3 (FLT3) mutations are linked to poor prognosis in AML and resistance to clinically approved FLT3 inhibitors. Previously, we reported a novel benzimidazole‐based FLT3 inhibitor, 4ACP, with nanomolar activities against FLT3‐ITD and...

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PMID: 40346763
DOI: 10.1002/ardp.70002

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