Article
Cross-resistance mechanism of respiratory syncytial virus against structurally diverse entry inhibitors.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2014
Yan Dan, Lee Sujin, Thakkar Vidhi D, Luo Ming, Moore Martin L, Plemper Richard Karl
Abstract excerpt
Respiratory syncytial virus (RSV) is a leading pediatric pathogen that is responsible for a majority of infant hospitalizations due to viral disease. Despite its clinical importance, no vaccine prophylaxis against RSV disease or effective antiviral therapeutic is available. In this study, we established a robust high-throughput drug screening protocol by using a recombinant RSV reporter virus to expand the pool...
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