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Article

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants.

Journal of enzyme inhibition and medicinal chemistry - 1 Dec 2022

Im Daseul, Jun Joonhong, Baek Jihyun, Kim Haejin, Kang Dahyun, Bae Hyunah, Cho Hyunwook, Hah Jung-Mi

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhibitors based on the structural optimisation of previous FLT3 inhibitors. Derivatives were synthesised as benzamide 8a-k, 8n-z, and phenyl urea 8l-m, with various...

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Identifiers

PMID: 35067150
DOI: 10.1080/14756366.2021.2020772
PMCID: PMC8788362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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