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Article

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor

29 Jan 2005

Abstract excerpt

BMS-433771 is an orally bioavailable respiratory syncytial virus (RSV) inhibitor, functioning through inhibition of viral F protein-induced membrane fusion. The compound is active against both A and B groups of RSV, with an average EC(50) of 20 nM. BMS-433771 is also efficacious against RSV infection in two rodent models when dosed orally prior to infection. The compound possesses good pharmacokinetic properties,...

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PMID: 15681582
DOI: 10.1093/jac/dkh558

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