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Article

Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation.

Oncotarget - 15 Dec 2014

Zheng Zhong, He Xiangyi, Xie Chanlu, Hua Sheng, Li Jianfang, Wang Tingfeng, Yao Mu, Vignarajan Soma, Teng Ying, Hejazi Leila, Liu Bingya, Dong Qihan

Abstract excerpt

A constitutive activation of protein kinase B (AKT) in a hyper-phosphorylated status at Ser473 is one of the hallmarks of anti-EGFR therapy-resistant colorectal cancer (CRC). The aim of this study was to examine the role of cytosolic phospholipase A2α (cPLA2α) on AKT phosphorylation at Ser473 and cell proliferation in CRC cells with mutation in phosphoinositide 3-kinase (PI3K). AKT phosphorylation at Ser473 was...

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Identifiers

PMID: 25365190
DOI: 10.18632/oncotarget.2639
PMCID: PMC4322978

Genes

DLD
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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