Article
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.
Cell - 15 Jun 2007
Walkley Carl R, Olsen Gemma Haines, Dworkin Sebastian, Fabb Stewart A, Swann Jeremy, McArthur Grant A, Westmoreland Susan V, Chambon Pierre, Scadden David T, Purton Louise E
Abstract excerpt
Myeloproliferative syndromes (MPS) are a heterogeneous subclass of nonlymphoid hematopoietic neoplasms which are considered to be intrinsic to hematopoietic cells. The causes of MPS are largely unknown. Here, we demonstrate that mice deficient for retinoic acid receptor gamma (RARgamma), develop MPS induced solely by the RARgamma-deficient microenvironment. RARgamma(-/-) mice had significantly increased...
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