Article
Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice.
Haematologica - 1 Feb 2017
Xin Junping, Breslin Peter, Wei Wei, Li Jing, Gutierrez Rafael, Cannova Joseph, Ni Allen, Ng Grace, Schmidt Rachel, Chen Haiyan, Parini Vamsi, Kuo Paul C, Kini Ameet R, Stiff Patrick, Zhu Jiang, Zhang Jiwang
Abstract excerpt
Acquired aplastic anemia is an autoimmune-mediated bone marrow failure syndrome. The mechanism by which such an autoimmune reaction is initiated is unknown. Whether and how the genetic lesions detected in patients cause autoimmune bone marrow failure have not yet been determined. We found that mice with spontaneous deletion of the TGFβ-activated kinase-1 gene in a small subset of hematopoietic cells developed...
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