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Article

Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling.

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2013

Ghiaur Gabriel, Yegnasubramanian Srinivasan, Perkins Brandy, Gucwa Jessica L, Gerber Jonathan M, Jones Richard J

Abstract excerpt

The high expression of aldehyde dehydrogenase 1, also known as retinaldehyde dehydrogenase, by hematopoietic stem cells (HSCs) suggests an important role for retinoic acid (RA) signaling in determining the fate of these cells. We found that primitive human bone marrow-derived CD34(+)CD38(-) cells not only highly express aldehyde dehydrogenase 1, but also the RA receptor α. Despite the up-regulation of early...

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Identifiers

PMID: 24043786
DOI: 10.1073/pnas.1305937110
PMCID: PMC3791732

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